Concepedia

Down-regulation of CXCR2 on Neutrophils in Severe Sepsis Is Mediated by Inducible Nitric Oxide Synthase–derived Nitric Oxide

Fabrício Rios-Santos, José C. Alves‐Filho, Fabrício Oliveira Souto, Fernando Spiller, Andressa de Freitas, Celina M.C. Lotufo, Milena Botelho Pereira Soares, Ricardo Ribeiro dos Santos, Mauro Martins Teixeira, Fernando Q. Cunha

American Journal of Respiratory and Critical Care Medicine · 2006 · 162 citations · 45 references

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Abstract

These results highlight evidences that the failure of neutrophils to migrate to an infection focus during severe sepsis is associated with excessive NO production and NO-dependent regulation of the expression of CXCR2 on the neutrophil surface.

References

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The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor

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CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in Murine<i>Pseudomonas aeruginosa</i>Pneumonia

Wan C. Tsai, Robert M. Strieter, Borna Mehrad et al. · Infection and Immunity · 2000 · 275 citations · Full text