Detection and characterization of hepatitis B virus of anti‐hepatitis B core antigen–reactive blood donors in Quebec with an in‐house nucleic acid testing assay

Abstract

The 3.25 percent HBV DNA positivity rate among the anti-HBc-reactive donations and more particularly the low level of HBV DNA observed in occult donations underline the importance of the use of a sensitive assay to detect HBV DNA in conjunction with other markers. The HBV genetic diversity found in our donor population reflects the province demographics, particularly in the Montreal area where most of the positive donors were from.