Cisplatin-mediated c-myc overexpression and cytochrome c (cyt c) release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase 3 and caspase 9, likely responsible for the TRAIL-sensitizing effect of cisplatin

Publication | Closed Access

DOI

Citations

References

2015

Year

Xingchao Zhu, Kaiguang Zhang, Qiaomin Wang, Si Chen, Yawen Gou, Yufang Cui, Qin Li

Medical Oncology

Signal TransductionSignaling PathwayCyt CApoptosisCell DeathCytochrome CRadiation OncologyMedicineCell BiologyDeath Receptors Dr4