Concepedia

Clinical significance of the 21‐gene signature (Oncotype DX) in hormone receptor‐positive early stage primary breast cancer in the Japanese population

Masakazu Toi, Hiroji Iwata, Takeharu Yamanaka, Norikazu Masuda, Shinji Ohno, Seigo Nakamura, Takahiro Nakayama, Masahiro Kashiwaba, Shunji Kamigaki, Katsumasa Kuroi

Cancer · 2010 · 112 citations · 9 references

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Abstract

This is the first report to show that the 21-gene signature has value in providing prognostic information in Asian populations with ER-positive, lymph node-negative breast cancer.

References

9

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

Soonmyung Paik, Steven Shak, Gong Tang et al. · New England Journal of Medicine · 2004 · 6.3K citations · Full text

Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer

Soonmyung Paik, Gong Tang, Steven Shak et al. · Journal of Clinical Oncology · 2006 · 2.6K citations

Proposal for Standardized Definitions for Efficacy End Points in Adjuvant Breast Cancer Trials: The STEEP System

Clifford A. Hudis, William E. Barlow, Joseph P. Costantino et al. · Journal of Clinical Oncology · 2007 · 860 citations · Full text

Measurement of Gene Expression in Archival Paraffin-Embedded Tissues

Maureen Cronin, Mylan Pho, Debjani Dutta et al. · American Journal Of Pathology · 2004 · 545 citations · Full text

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A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients

Laurel A. Habel, Steven Shak, Marlena K Jacobs et al. · Breast Cancer Research · 2006 · 478 citations · Full text