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Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: Synthesis, biochemical screening, and structure–activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines

Medicinal ChemistryBiochemistryMedicineNatural SciencesBiochemical ScreeningRational Drug DesignDrug DevelopmentStructure–activity CorrelationsPharmacologyPharmaceutical ChemistryInhibitory ActivityDrug Discovery