Concepedia

Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats

Donald Seyfried, Yuxia Han, Yi Li, Jieli Chen, Michael Chopp

Journal of neurosurgery · 2006 · 78 citations · 26 references

DOI

Abstract

Intravenous administration of hBMSCs significantly improves neurological function in rats subjected to ICH. This improvement in the treated animals is associated with reduced tissue loss and increased local presence of the hBMSCs, mitotic activity, immature neurons, synaptogenesis, and neuronal migration.

References

26

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck et al. · Science · 1999 · 20.9K citations

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Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Jieli Chen, Yi Li, Lei Wang et al. · Stroke · 2001 · 1.7K citations · Full text

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

Gene Kopen, Darwin J. Prockop, Donald G. Phinney · Proceedings of the National Academy of Sciences · 1999 · 1.6K citations

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Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats

J Chen, Paul R. Sanberg, Y Li et al. · Stroke · 2001 · 1.3K citations · Full text

Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

Ruth F. Pereira, Kenneth W. Halford, Michael D. O’Hara et al. · Proceedings of the National Academy of Sciences · 1995 · 915 citations · Full text

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