Publication | Closed Access
Phenanthroline Unit as a Building Block for Carbohydrate Receptors
44
Citations
43
References
2008
Year
Medicinal ChemistryBiochemistryFunctional SelectivityAcyclic Receptor 1Natural SciencesMedicineG Protein-coupled ReceptorReceptor (Biochemistry)Neuropeptide ReceptorPowerful Carbohydrate ReceptorPharmacotherapyNon-peptide LigandChemical BiologyPharmacologyPhenanthroline UnitCompound 1Drug Discovery
An acyclic receptor 1, containing phenanthroline- and aminopyridine-based recognition sites, has been established as a powerful carbohydrate receptor. Compared to the previously described acyclic receptors, compound 1 shows significantly higher binding affinities as well as selectivities, which are quite different from those of the earlier systems. The phenanthroline unit has been established as a valuable building block for the construction of effective and selective carbohydrate receptors.
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