Erythropoietin Increases Survival and Attenuates Fulminant Hepatic Failure Injury Induced by d-Galactosamine/Lipopolysaccharide in Mice

Abstract

The administration of rhEPO brought about increased survival and attenuation of the hepatic injury. This was associated with decreased hepatic NF-κB and JNK activation and thus TNF-α and IL-1β levels. These findings have important implications for the potential use of rhEPO in FHF.