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Membrane Anchoring and Intervesicle Transfer of a Derivative of the Antibiotic Moenomycin A
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1999
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Bioorganic ChemistryMembrane AnchoringIntervesicle TransferAntibiotic AdjuvantAntimicrobial ChemotherapyAntibiotic Moenomycin ADrug ResistanceMembrane TransportBiophysicsBiological ActivityBiochemistryBiochemical InteractionMembrane BiologyAntimicrobial CompoundBiomolecular EngineeringMoenomycin ADiffusion-mediated Intervesicle TransferAntibioticsNatural SciencesCellular BiochemistryMedicine
The anchoring of moenomycin A (1) to the bacterial cell cytoplasmic membrane is essential for its biological activity. The first details of the strength of this interaction and the kinetics of the diffusion-mediated intervesicle transfer have been obtained by means of fluorescence spectroscopic methods using a coumarin-labeled moenomycin A derivative.