Chemical Communications · 2000 · 17 citations · 12 references
Life SciencesBiochemistryMolecular BiologyMolecular VirologyNucleic Acid ChemistryVirologyAntiretroviral TherapyNucleobase ChemistryPeptide ChemistryRibonucleic Acid (Rna) ChemistryRna-binding ProteinsViral Rna BiologyAmino Acid Side Chain ChemistryDouble-stranded Viral RnaNucleobase AnaloguesNucleoside AnalogsPeptide Nucleic Acid Synthesis
A nucleobase-conjugated peptide, derived from HIV-1 Rev, was designed and synthesized, and the peptide which contained the cytosine moiety at the L-α-amino acid side chain bound RRE IIB RNA with high affinity and high specificity.
12
α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex
John L. Battiste, Hongyuan Mao, N. Sambasiva Rao et al. · Science · 1996 · 596 citations