Stretching and twisting of the DNA duplexes in coarse-grained dynamical models

Abstract

Three coarse-grained models of the double-stranded DNA are proposed and\ncompared in the context of mechanical manipulation such as twisting and various\nschemes of stretching. The models differ in the number of effective beads\n(between two and five) representing each nucleotide. They all show similar\nbehavior and, in particular, lead to a torque-force phase diagrams\nqualitatively consistent with experiments and all-atom simulations.\n