Assessing a Non-Traditional View of Adipogenesis: Adipocyte Dedifferentiation – Mountains or Molehills?

Abstract

Based on our studies we propose the following hypothesis: mature, lipid-containing adipocytes possess the ability to undergo symmetrical or asymmetrical cell division, without losing lipid. While our research to discern the mechanism(s) involved in what we have termed 'dedifferentiation' of adipocytes is ongoing, we have identified several roadblocks to our work in this area. However, due to the newness of this research, we believe that none of these problems discounts the potential importance of our initial observations, or the excitement of contributing knowledge in the area. In this manuscript we address some of these problems and suggest possible solutions in an attempt to make 'molehills' out of 'mountains.'