<i>N</i>‐Alkylations of <i>N</i>H‐Sulfoximines and <i>N</i>H‐Sulfondiimines with Alkyl Halides Mediated by Potassium Hydroxide in Dimethyl Sulfoxide

Abstract

Abstract A general method for the N ‐alkylation of N H‐sulfoximines and N H‐sulfondiimines has been developed, employing alkyl bromides with KOH in DMSO at room temperature. A variety of previously inaccessible N ‐alkylated sulfoximines and sulfondiimines was prepared in good to excellent yields (up to 97%). As an application, the conditions were used to access the biologically active Suloxifen. magnified image