RELAXANT EFFECTS OF ISOPROTERENOL AND SELECTIVE β3-ADRENOCEPTOR AGONISTS ON NORMAL, LOW COMPLIANT AND HYPERREFLEXIC HUMAN BLADDERS

Abstract

beta-adrenoceptor stimulation is an effective way of relaxing the human detrusor and the effect is similar in normal and neurogenic bladders. A major portion of the relaxant effect of isoproterenol is mediated via beta3-adrenoceptor stimulation. Clinical trials may reveal whether this method is useful for treating bladder overactivity.