INHIBITION OF GROWTH HORMONE RELEASE IN HUMANS BY SOMATOSTATIN.

Abstract

Synthetic (linear) somatostatin (SRIF, somatotropin-release inhibiting factor) abolished the elevation of serum GH concentration induced in normal human subjects by the administration of L-dopa and arginine. Within the dose used (250 μg, iv and 500 μg constant infusion) somatostatin. did not inhibit the rise in circulating PRL normally observed with arginine infusion nor did it modify basal levels of serum GH, TSH, PRL, FSH and LH.