Early Versus Delayed Restoration of Flow With Temporary Vascular Shunt Reduces Circulating Markers of Injury in a Porcine Model

Abstract

This study provides physiologic insight into the benefit of shunts in a model of extremity ischemia. Early shunting protects the extremity from further ischemic insult and reduces circulating markers of tissue injury. Additionally, the presence of a shunt does not increase the Ischemic Injury Index and patency is maintained in the absence of heparinization.