Comparative Evaluation of Lesion Enhancement Using 1 M Gadobutrol vs. 2 Conventional Gadolinium Chelates, All at a Dose of 0.1 mmol/kg, in a Rat Brain Tumor Model at 3 T

Abstract

The results of this study show significantly higher brain tumor SNR and CNR postcontrast for gadobutrol compared with gadopentetate dimeglumine and gadoterate meglumine at 3 T. Injecting the same gadolinium chelate dose on a weight basis, tumor mean SNR gains were superior for gadobutrol at all acquired postcontrast time points. This result with gadobutrol may facilitate better brain tumor detection in the presence of blood-brain barrier disruption.