Arrhythmogenic Autoantibodies Against Calcium Channel Lead to Sudden Death in Idiopathic Dilated Cardiomyopathy

Abstract

Our results demonstrate for the first time to our knowledge that there is a high incidence of sudden death and VT in CC-AAbs-positive patients with DCM. Furthermore, experimental data from ex vivo systems suggest that CC-AAbs might induce VT by prolongation of APD and triggered activity by EAD.