Chiral Amine−Polyoxometalate Hybrids as Highly Efficient and Recoverable Asymmetric Enamine Catalysts

Abstract

Chiral amine and polyoxometalate (POM) acids were combined to give highly efficient, stereoselective, and recoverable enamine-based catalysts. Less than 1 mol % of chiral amine loading was sufficient for good catalytic activity, and the catalyst could be recovered and reused 6 times with unchanged enantioselectivity and slightly decreased activity.