Baseline deconvolution, phase correction, and signal quantification in fourier localized spectroscopic imaging

Abstract

Lineshapes of spectra obtained through chemical-shift imaging are often distorted due to the delay in sampling necessary for application of phase-encoding gradients. We have developed an automated fitting procedure which simultaneously performs signal quantification, phase correction, and baseline deconvolution of such spectra. The fit is based on the maximum likelihood method and can be implemented in either the time or the frequency domain.