Uptake of Radioactive Sulfur by Chondrosarcomas in Man

Abstract

SummaryTwo patients with chondrosarcomas Received respectively 6.7 and 2.9 millicuries of S-35 as sodium sulfate. Tissue samples were obtained at operations and at necropsy several days after the injection and were analyzed for S-35 content. The highest concentrations of isotope were found in the chondrosarcomas. Progressively smaller amounts were found in other tissues in the sequence: cartilage, bone marrow, spleen, kidney, skin, liver, bone, adipose tissue, and muscle. Radioautographs indicated maximum concentration in the growing portions of the chondrosarcoma and in those containing abundant ground substance. The findings are discussed in relation to the possibility of diagnostic or therapeutic applications.