Otolaryngology · 2007 · 337 citations · 9 references
MedicineOtolaryngologySurgeryOtolaryngologic SurgeryPharyngeal SurgerySleep MedicineAirway ImprovementAirway ObstructionAirway SurgerySleep SurgerySleep-disordered BreathingTonsil SurgeryApnea-hypopnea Index ReductionExpansion Sphincter PharyngoplastyFriedman ClassificationObstructive Sleep Apnea TherapyObstructive Sleep Apnea TreatmentOxygen SaturationPalatine TonsilsSleep Apnea Outcome Measurement
OBJECTIVE: In this study, we assessed the efficacy of a new method (expansion sphincter pharyngoplasty [ESP]) to treat obstructive sleep apnea. STUDY DESIGN: We conducted a prospective, randomized controlled trial. METHODS: Forty-five adults with small tonsils, body mass index less than 30 kg/m2, of Friedman stage II or III, of type I Fujita, and with lateral pharyngeal wall collapse were selected for the study. RESULTS: The mean body mass index was 28.7 kg/m2. The apnea-hypopnea index improved from 44.2 +/- 10.2 to 12.0 +/- 6.6 (P < 0.005) following ESP and from 38.1 +/- 6.46 to 19.6 +/- 7.9 in the uvulopalatopharyngoplasty group (P < 0.005). Lowest oxygen saturation improved from 78.4 +/- 8.52% to 85.2 +/- 5.1% in the ESP group (P = 0.003) and from 75.1 +/- 5.9% to 86.6 +/- 2.2% in the uvulopalatopharyngoplasty group (P < 0.005). Selecting a threshold of a 50% reduction in apnea-hypopnea index and apnea-hypopnea index less than 20, success was 82.6% in ESP compared with 68.1% in uvulopalatopharyngoplasty (P < 0.05). CONCLUSION/SIGNIFICANCE: The ESP may offer benefits in a selected group of OSA patients.
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Pathogenesis of upper airway occlusion during sleep
John E. Remmers, William J. deGroot, Eberhardt K. Sauerland et al. · Journal of Applied Physiology · 1978 · 1.9K citations
R J Schwab, K B Gupta, Warren B. Gefter et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 811 citations
Medicine, Anatomy, Oral Radiology +15