Organic Letters · 2008 · 11 citations · 23 references
Life SciencesMedicinal ChemistryPharmacologyDrug DiscoveryNeurochemistryNeuropharmacologyCholinergic PharmacologyNeurotransmissionNeurotransmitter ReceptorsNeurotransmitter SystemsNicotine PharmacologySynaptic TransmissionBiological CharacterizationCholinergic Receptor PharmacologyNatural Product SynthesisNatural Product Total SynthesisNeuroactive Natural ProductsNicotinic Receptor PharmacologyStructure ConfirmationTotal Synthesis-derived Analogues
The first total synthesis of the natural product 3-hydroxy-11-norcytisine (1), structurally related to cytisine (2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
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Total Synthesis of (±)-Cytisine
Brian T. O’Neill, Daniel Yohannes, Mark W. Bundesmann et al. · Organic Letters · 2000 · 89 citations