Domino cyclization–alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

Abstract

A practical and efficient protocol for the one-pot synthesis of 2,3-substituted indoles was developed via a palladacycle catalyzed domino cyclization-alkylation reaction involving 2-alkynylanilines and allylic alcohols under mild conditions without any additives.