Chronic Daily Headache Prophylaxis With Tizanidine: A Double‐Blind, Placebo‐Controlled, Multicenter Outcome Study

Abstract

The results support tizanidine as an effective prophylactic adjunct for chronic daily headache, including migraine, migrainous headache, and tension-type headache. These results also suggest the possible importance of an alpha2-adrenergic mechanism underlying the pathophysiology of this spectrum of headache disorders.