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A Cytotoxic Acetophenone with a Novel Skeleton, Isolated fromCynanchum taiwanianum
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1999
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BiochemistryAntiparasitic AgentMedicineBioassay-guided IsolationPathologyPhytopharmacologyToxicologyNovel SkeletonNovel AcetophenonePharmacologyCompound 1Cynandione BDrug Discovery
A novel acetophenone, cynantetrone (1), was isolated from the rhizome of Cynanchum taiwanianum and its structure determined by spectroscopic methods. Compound 1 and cynandione B (3) showed significant in vitro cytotoxicity against T-24 cell lines, and 3 also against PLC/PRF/5 cell lines.