An Efficient Route to Quinolines and Other Compounds by Iron‐Catalysed Cross‐Dehydrogenative Coupling Reactions of Glycine Derivatives

Abstract

Abstract A simple method has been developed for functionalizing glycine derivatives by iron‐catalysed cross‐dehydrogenative coupling (CDC) reactions. In particular, N ‐arylglycine derivatives reacted with alkynes by oxidative C–H/C–H coupling reactions to provide a series of substituted quinolines starting from commercially inexpensive materials. Moreover, N ‐arylglycine esters can be oxidatively coupled to ketones by using FeCl 3 in the presence of DDQ.