Concepedia

Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells

Takeshi Kitazaki, Mikio Oka, Yoichi Nakamura, Junji Tsurutani, Seiji Doi, Masa Yasunaga, Masaaki Takemura, Hikaru Yabuuchi, Hiroshi Soda, Shigeru Kohno

Lung Cancer · 2005 · 179 citations · 13 references

DOI

Concepts

References

13

Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer

Masahiro Fukuoka, Seiji Yano, Giuseppe Giaccone et al. · Journal of Clinical Oncology · 2003 · 2.9K citations

, , +13

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

Fortunato Ciardiello, Giampaolo Tortora · PubMed · 2001 · 988 citations

, , +17

Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.

Fortunato Ciardiello, Rosa Caputo, Roberto Bianco et al. · PubMed · 2001 · 646 citations

, , +17

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

Balázs Sarkadi, Elmer M. Price, R. C. Boucher et al. · Journal of Biological Chemistry · 1992 · 632 citations · Full text

, , +7

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

J S Lee, K Paull, Curtis Hose et al. · Molecular Pharmacology · 1994 · 340 citations

, , +11