Effect of inhibiting HMG‐CoA reductase on 7α‐hydroxy‐4‐cholesten‐3‐one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up‐regulation of the latter pathway

Abstract

Atorvastatin decreases the rate of BA synthesis only if the latter is up-regulated by PIB or BA sequestrants, presumably by limiting the supply of newly synthesized free cholesterol.