Dehydrogenative Functionalization of C(sp³)–H Bonds Adjacent to a Heteroatom Mediated by Oxoammonium Salts

Abstract

Abstract The first oxoammonium salt mediated formation of C–C bonds from benzylic C(sp 3 )–H bonds adjacent to an oxygen or nitrogen atom by dehydrogenative coupling with enolizable carbonyls has been developed. The use of these oxidants in combination with catalytic amounts of Fe(OTf) 2 as Lewis acid allows the reaction to be carried out under mild conditions, leading to the corresponding coupling products in moderate to good yields.