IL-1β Triggered by Peptidoglycan and Lipopolysaccharide through TLR2/4 and ROS-NLRP3 Inflammasome–Dependent Pathways Is Involved in Ocular Behçet's Disease

Abstract

The results suggest that TLR2/4 expression in MDMs from active BD patients is significantly increased. Interaction of TLR2/4 with their ligands PGN/LPS is involved in BD pathogenesis, possibly by the induction of IL-1β through a ROS-NLRP3-dependent pathway.