Interleukin‐1 Stimulates Human Uterine Prostaglandin Production Through Induction of Cyclooxygenase‐2 Expression

Abstract

IL-1 increases PG production by myometrium by increased COX-2 expression. NS-398 completely blocks IL-1-induced PG production. With intrauterine infection, IL-1 may induce labor through the autocrine production of uterotonic PGs.