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Reevaluation of the disulfiram-alcohol reaction in man.
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1977
Year
Molecular PharmacologyIndividual PredispositionPharmaceutical ScienceAldehyde DehydrogenaseBiochemistryAddictionMedicinePhysiologyForensic ToxicologyDisulfiram-alcohol ReactionDopaminePharmacologyAlcohol DehydrogenasesBlood Acetaldehyde LevelHealth Sciences
The intensity of the disulfiram-alcohol reaction is found to depend on the blood acetaldehyde level, a disulfiram-induced predisposition reflected by alkalosis, and an individual predisposition reflected by dopamine-beta-hydroxylase activity.