Facile synthesis of 2,6‐diaryl‐4‐secondary aminonicotinonitriles and highly substituted unsymmetrical 2,2′‐bipyridines

Abstract

Abstract magnified image The ring transformation of 2H ‐pyran‐2‐one by N ‐aryl amidine in the presence of KOH in DMF at room temperature resulted in a facile synthesis of the 2,6‐diaryl‐4‐secondary aminonicotinonitrile and highly substituted unsymmetrical 2,2′‐bipyridines in moderate yield. J. Heterocyclic Chem., (2010).

References

Page 1

	Year	Citations
The Specific Synthesis of Pyridines and Oligopyridines<sup>1</sup> Fritz Kröhnke Synthesis Terpyridines 5Diversity Oriented SynthesisDerivativesSpecific SynthesisOligopyridines 3	1976	735
Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines M. F. GORDEEV, Dinesh V. Patel, Eric M. Gordon The Journal of Organic Chemistry	1996	252
Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A<sub>3</sub> Adenosine Receptor Antagonists An‐Hu Li, Stefano Moro, Nancy E. Forsyth, Journal of Medicinal Chemistry	1999	179
Sequential Amination/Annulation/Aromatization Reaction of Carbonyl Compounds and Propargylamine: A New One-Pot Approach to Functionalized Pyridines Giorgio Abbiati, Antonio Arcadi, Gabriele Bianchi, The Journal of Organic Chemistry Functionalized PyridinesChemical EngineeringEngineeringHeterocyclicGeneral One-pot Synthesis	2003	157
A Versatile Strategy for the Synthesis of Functionalized 2,2‘-Bi- and 2,2‘:6‘,2‘ ‘-Terpyridines <i>via</i> Their 1,2,4-Triazine Analogues Valery N. Kozhevnikov, Dmitry N. Kozhevnikov, Manfred Zabel, The Journal of Organic Chemistry	2003	155
Syntheses Using the Michael Adddition of Phridinium Salts Fritz Kröhnke, Wilfried Zecher, Jürgen Curtze, Angewandte Chemie International Edition in English Active Methylene GroupsDerivativesInternal Michael AdditionMichael AdditionOrganic Chemistry	1962	134
CLXXV.—The formation and reactions of imino-compounds. Part I. Condensation of ethyl cyanoacetate with its sodium derivative H. Le Baron, Frederick George Percy Remfry, Jocelyn Field Thorpe Journal of the Chemical Society Transactions	1904	114
Novel Derivatives of 2-Pyridinemethylamine as Selective, Potent, and Orally Active Agonists at 5-HT<sub>1A</sub> Receptors Bernard Vacher, Bernard Bonnaud, Philippe Funes, Journal of Medicinal Chemistry	1999	107
Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist Zhiguo J. Song, Mangzhu Zhao, Richard Desmond, The Journal of Organic Chemistry Chiral CenterOrganic ChemistryPeptide SciencePharmacotherapyMolecular Pharmacology	1999	96
Synthesis of Aminonicotinonitriles and Diaminopyridines through Base-Catalyzed Ring Transformation of 2<i>H</i>-Pyran-2-ones Farhanullah, Nidhi Agarwal, Atul Goel, The Journal of Organic Chemistry EngineeringBiochemistryBase-catalyzed Ring TransformationNatural SciencesDiversity-oriented Synthesis	2003	64

Page 1