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Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2

Viral EvolutionMultiple MutationsGeneticsPathogenesisViral PathogenesisVirologySingle MutationMolecular GeneticsOther SitesSystems BiologyMedicineViral Structural ProteinViral Genetics