Concepedia

Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles

Tamio Mizutani, Kiyomi Suzuki

Toxicology Letters · 1996 · 27 citations · 8 references

Concepts

Relative HepatotoxicityMedicinal ChemistryBiochemistryMedicineRing Cleavage MetabolitesNatural SciencesToxicologyHepatotoxicityExperimental ToxicologyPharmacologyDrug-induced Liver InjuryToxicological MechanismSubstituted Phenyl

References

8

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Owen W. Griffith, A Meister · Journal of Biological Chemistry · 1979 · 1.7K citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Specific Inhibition +13

Formation of toxic metabolites from thiabendazole and other thiazoles in mice. Identification of thioamides as ring cleavage products.

Tetsuya Mizutani, Kumiko Yoshida, Souichirou Kawazoe · Drug Metabolism and Disposition · 1994 · 53 citations

Relative hepatotoxicity of substituted thiobenzamides and thiobenzamide-S-oxides in the rat

Robert P. Hanzlik, John R. Cashman, George J. Traiger · Toxicology and Applied Pharmacology · 1980 · 46 citations

Medicine, Liver Physiology, Substituted Thiobenzamides +7

Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat

Robert P. Hanzlik, Kamlesh P. Vyas, George J. Traiger · Toxicology and Applied Pharmacology · 1978 · 37 citations

Pharmacological Study, Biochemistry, Medicine +11

Aminophenyl Oxazoles and Thiazoles

Bernard Friedman, Meredith Sparks, Roger Adams · Journal of the American Chemical Society · 1937 · 36 citations

Engineering, Altmetric Attention Score, Bibliometrics +16