European Surgical Research · 2008 · 46 citations · 0 references
MedicinePharmacologyToxicologyHepatologyMetabolismToxicologic PathologyCirrhosisHepatic MetabolismHepatic PathophysiologyHepatic ToxicityLiver DiseaseLiver PhysiologyAmino AcidsBlood Glucose RegulationBranched-chain Amino AcidsCarbon Tetrachloride HepatotoxicityCarbon Tetrachloride ToxicityLiver Disease Effects On MetabolismLiver Toxicity AssessmentPlasma-to-kidney Concentration Ratio
The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.