Australian and New Zealand Journal of Medicine · 1986 · 35 citations · 6 references
PharmacyCardiologyPharmacologyCardiovascular PharmacotherapyDrug RepurposingRenal PharmacotherapyCardiac MedicationsCardiac PharmacotherapyDiuretic TherapyHeart FailureHeart Failure PharmacotherapyInotropic TherapyCombination Drug TherapyCongestive Heart Failure ManagementHeart Failure DiuresisHeart Failure PharmacologyRenin-angiotensin-aldosterone System InhibitionSpironolactone Therapy
Three cases are described of severe congestive heart failure which failed to respond to digitalis, high doses of loop diuretics, and converting-enzyme inhibitors. The addition of spironolactone produced a substantial diuresis associated with clinical and radiological improvement in each case. Although a reversible deterioration in renal function was observed, this drug combination represents a therapeutic option in end-stage heart failure.
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