Concepedia

The Impact of Depot GnRH Agonist on AMH Levels in Healthy Reproductive-Aged Women

H. Irene Su, Kevin Maas, Patrick M. Sluss, R. Jeffrey Chang, Janet E. Hall, Hadine Joffe

The Journal of Clinical Endocrinology & Metabolism · 2013 · 71 citations · 21 references

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Abstract

Significant changes in AMH levels occur in the first 4 weeks after depot leuprolide administration, suggesting that AMH may not be a reliable marker of ovarian reserve during this interval. Changes in AMH occurred independent of gonadotropin levels, supporting a direct effect of GnRHa on granulosa cell expression of AMH or an indirect effect of GnRHa on the development and/or dynamics of the follicle pool.

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