Association of the <b><i>hsa-mir-499</i></b> (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population

Abstract

<b><i>Background: </i></b>Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA <i>hsa-mir-499</i> with the risk of gastric cancer (GC) in the Chinese population. <b><i>Patients and Methods: </i></b>The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. <b><i>Results: </i></b>There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes. <b><i>Conclusion: </i></b>The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.