BMJ · 1981 · 124 citations · 10 references
Life SciencesImmunologyInternal MedicineAutoimmunityImmunogeneticsRheumatologyAutoimmune Disease Susceptibility GenesAutoimmune DiseasesAutoimmune Rheumatic DiseasesGenetic Susceptibility To AutoimmunityHla TypingRheumatoid ArthritisHla Allele Frequency DistributionHla Allele PolymorphismHla AllelesHla Autoimmune Disease AssociationsHla Genotype AssociationsHla Risk AllelesSerological Antigens
Thr prevalence of HLA-DR antigens was determined in a group of white patients with rheumatoid arthritis, similar patients originating from the Indian subcontinent, and corresponding controls. Rheumatoid arthritis was found to be highly associated with DR4 in the white patients but with DR1 in the Indian patients. These results raise the possibility that the DR antigens themselves do not play a part in increasing susceptibility to rheumatoid arthritis, but the locus for increased susceptibility is probably closely linked to the DR locus.
10