Publication | Closed Access
Asymmetric Reductive Coupling of Dienes and Aldehydes Catalyzed by Nickel Complexes of Spiro Phosphoramidites: Highly Enantioselective Synthesis of Chiral Bishomoallylic Alcohols
165
Citations
20
References
2007
Year
High YieldsAsymmetric CatalysisChemical EngineeringNickel ComplexesEngineeringCross-coupling ReactionOrganic ChemistryOrganometallic CatalysisCatalysisExcellent DiastereoselectivitiesChemistryChiral Bishomoallylic AlcoholsBishomoallylic AlcoholsAsymmetric Reductive CouplingEnantioselective SynthesisBiomolecular Engineering
A highly efficient nickel-catalyzed asymmetric reductive coupling of dienes and aldehydes has been realized by using bulky spirobiindane phosphoramidite ligands, affording bishomoallylic alcohols in high yields with excellent diastereoselectivities and enantioselectivities.
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