Concepedia

Asymmetric Reductive Coupling of Dienes and Aldehydes Catalyzed by Nickel Complexes of Spiro Phosphoramidites:  Highly Enantioselective Synthesis of Chiral Bishomoallylic Alcohols

Yun Yang, Shou‐Fei Zhu, Haifeng Duan, Chang‐Yue Zhou, Lixin Wang, Qi‐Lin Zhou

Journal of the American Chemical Society · 2007 · 167 citations · 20 references

DOI

Concepts

Abstract

A highly efficient nickel-catalyzed asymmetric reductive coupling of dienes and aldehydes has been realized by using bulky spirobiindane phosphoramidite ligands, affording bishomoallylic alcohols in high yields with excellent diastereoselectivities and enantioselectivities.

References

20

Catalytic Asymmetric Reductive Coupling of Alkynes and Aldehydes:  Enantioselective Synthesis of Allylic Alcohols and α-Hydroxy Ketones

Karen M. Miller, Wei‐Sheng Huang, Timothy F. Jamison · Journal of the American Chemical Society · 2003 · 296 citations

, , +9

Monodentate Chiral Spiro Phosphoramidites: Efficient Ligands for Rhodium-Catalyzed Enantioselective Hydrogenation of Enamides

Aiguo Hu, Yu Fu, Jian‐Hua Xie et al. · Angewandte Chemie International Edition · 2002 · 239 citations

, , +11

Polymer‐ and Dendrimer‐Bound Ti‐TADDOLates in Catalytic (and Stoichiometric) Enantioselective Reactions: Are pentacoordinate cationic Ti complexes the catalytically active species?

Dieter Seebàch, Roger Martí, Tobias Hintermann · Helvetica Chimica Acta · 1996 · 210 citations

, , +17

Novel and Highly Regio- and Stereoselective Nickel-Catalyzed Homoallylation of Benzaldehyde with 1,3-Dienes

Masanari Kimura, Akihiro Ezoe, Kazufumi Shibata et al. · Journal of the American Chemical Society · 1998 · 176 citations

, , +10

Regio- and Stereoselective Nickel-Catalyzed Homoallylation of Aldehydes with 1,3-Dienes

Masanari Kimura, Akihiro Ezoe, Masahiko Mori et al. · Journal of the American Chemical Society · 2006 · 173 citations

, , +15