Computer Graphics As A Tool For The Prediction Of The Stereoselectivity Of Enzyme Catalyzed Reactions. α-Cxhymotrypsin Catalyzed Hydrolysis Of Substituted Propanedioic Acid Diesters.

Abstract

Computer graphics can be used for the prediction of substrate specificity and stereoselectivity in the α-chymotrypsin catalyzed hydrolysis of Disubstituted propanedioic acid diesters. This enzyme catalyzed reaction is useful for the preparation of chiral starting materials, e.g. for the synthesis of optically pure α-methylaminoacids.