Structure of the porcine LH-and FSH-releasing Hormone.

Abstract

No AccessJournal of Urology1 Feb 2002Structure of the porcine LH-and FSH-releasing Hormone.I. The proposed amino acid sequence0110 0 H. Matsuo, Y. Baba, R.M.G. Nair, A. Arimura, and A.V. Schally H. MatsuoH. Matsuo V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , Y. BabaY. Baba V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , R.M.G. NairR.M.G. Nair V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , A. ArimuraA. Arimura V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author , and A.V. SchallyA.V. Schally V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA Supported by grants from V.A., USPHS AM-07467, and Population Council, New York, N.Y. to AVS. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(02)80326-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The complete amino acid sequence of porcine LH- and FSH-releasing hormone has been provisionally determined by the use on a micro-scale of the combined Edman-dansyl procedure coupled with the selective tritiation method for C-terminal analysis. These procedures were used directly on the digestion products of LH-RH with chymotrypsin and thermolysin, without separation of the fragments. Additional data were provided by high resolution mass spectral fragmentation of LH-RH. On the basis of these results, we propose the following decapeptide sequence for LH-RH: (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. References 1. : Recent Progress in Hormone Research1968; 24: 497. Google Scholar 2. : Biochem. Biophys. Res. Commun.1971; 42: 50. Google Scholar 3. : Biochem. Biophys. Res. Commun.1971; 43: 393. Google Scholar 4. : Biochem. Biophys. Res. Commun.1966; 22: 69. Google Scholar 5. : . : 1970. Google Scholar 6. : . : Academic Press1967: 139. Google Scholar 7. : Biochem. Biophys. Res. Commun.1969; 35: 175. Google Scholar 8. : . : Academic Press1967: 197. Google Scholar 9. : Biochem. Biophys. Acta.1969; 133: 369. Google Scholar 10. : Europ. J. Biochem.1969; 7: 463. Google Scholar 11. : Biochem J.1970; 119: 805. Google Scholar 12. : Chem. Pharm. Bull. (Japan)1970; 18: 890. Google Scholar © 2002 by American Urological Association, IncFiguresReferencesRelatedDetails Volume 167Issue 2 Part 2February 2002Page: 1011-1014 Advertisement Copyright & Permissions© 2002 by American Urological Association, IncMetrics Author Information H. Matsuo V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author Y. Baba V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author R.M.G. Nair V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author A. Arimura V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA More articles by this author A.V. Schally V.A. Hospital, New Orleans, LA, USA Tulane University School of Medicine, New Orleans, LA, USA Supported by grants from V.A., USPHS AM-07467, and Population Council, New York, N.Y. to AVS. More articles by this author Expand All Advertisement PDF downloadLoading ...