The Anticonvulsant Properties of 2-Methyl-3-<i>p</i>-Bromophenyl-3<i>H</i>-4-Quinazolone Hydrochloride (B.D.H. 1880) and Some Related Compounds

Abstract

Abstract Twenty-five 2-alkyl-3-aryl-3H-4-quinazolone derivatives, eight 2-aryl-3-alkyl-3H-4-quinazolone derivatives and six 2-alkyl-3-aryl- 3H-4-thioquinazolone derivatives were examined for orala nticonvulsant properties against leptazol induced convulsions in mice. 2-Methyl-3- p-bromophenyl-3H-4-quinazolone hydrochloride (B.D.H. 1880) was the most active compound and was therefore examined more fully. It is fourteen times more active than troxidone against leptazol and eight times more active against electroshock induced convulsions. B.D.H. 1880 also has a better therapeutic index than troxidone. It has approximately one-quarter the activity of phenytoin against leptazol and one-twelth the activity against electroshock-induced convulsions. B.D.H. 1880 and primidone have similar anticonvulsant properties against leptazol induced convulsions but B.D.H. 1880 is only one-third as active as primidone against electroshock induced convulsions.