Evidence for Early Impairment of Glucagon-Like Peptide 1-Induced Insulin Secretion in Human Type 2 (Non Insulin-Dependent) Diabetes - Concepedia

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Evidence for Early Impairment of Glucagon-Like Peptide 1-Induced Insulin Secretion in Human Type 2 (Non Insulin-Dependent) Diabetes

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Citations

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References

2002

Year

R Lugari, Alessandra Dei, D. Ugolotti, Lorenzo Finardi, Amelia Barilli, Cherie M. Ognibene, A Luciani, R Zandomeneghi, A Gnudi

Hormone and Metabolic Research

Abstract

1) The functional integrity of GLP-1 cells results as being seriously impaired even in the condition of mild diabetes; 2) the early peptide failure could contribute to the development of beta-cell deterioration which characterizes overt type 2 diabetes.