Transplantation · 2000 · 84 citations · 10 references
MedicineImmunologyNephrologyImmunizationKidney TransplantationTransplant ImmunologyImmunogenicity Of Therapeutic AntibodiesImmunosuppression In Kidney TransplantationImmunosuppression ManagementImmunosuppressive TherapyTransplant Infectious ComplicationsTransplant RejectionCombination Immunosuppressive RegimensImmunosuppressive Drug TherapyInfluenza TreatmentProtective Antibody TitersRenal Allograft ProtectionRenal Dysfunction After TransplantVaccination In Transplant RecipientsVaccination Responses After Transplant
BACKGROUND: Due to possible complications and treatment limitations, the prevention of influenza in renal transplant (RT) patients is highly indicated. METHODS: Forty-nine patients with a 1-year functioning RT subjected to two different immunosuppressive regimens and 37 healthy relatives (HR) were administered the anti-influenza vaccine as recommended for 1996 to 1997. Anti-influenza antibody, creatinine, and immunological markers were estimated at 1 and 3 months after vaccination. RESULTS: Three months after vaccination, 46.2% of the RT patients and 69% of the HR (P=0.06) showed protective antibody titers to influenza A (relative risk [RR]; 0.67; 95% confidence interval: 0.44-1.02). A total of 20.5% of the RT patients and 44.8% of the HR showed antibodies to influenza B (P=0.03). Despite these differences, the incidence of illness was similar. The immunosuppressive regimen had no effect on the antibody response. CONCLUSIONS: Although the RT patients showed a reduced antibody response, no negative effects on graft outcome were observed.
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Suppression of the humoral immune response by mycophenolate mofetil
Kenneth G. C. Smith, Nicole M. Isbel, Mike Catton et al. · Nephrology Dialysis Transplantation · 1998 · 182 citations
Medicine, Immunology, Pharmacology +17
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Teri Jo Mauch, Timothy G. Myers, Clifford E. Kashtan et al. · PEDIATRICS · 1994 · 81 citations