Science · 1963 · 57 citations · 4 references
MedicineObstetricsToxicologyDevelopmental ToxicologyEmbryologyReproductive ToxicologyCongenital MalformationsCongenital Oral AnomaliesPerinatal PharmacologyPregnancy PharmacologyPrenatal DevelopmentPrenatal ToxicityCritical Period EffectsDrug-induced TeratogenicityLower Jaw DevelopmentMaternal-fetal ToxicityMechanisms Of TeratogenesisPerinatal Drug ToxicityPrenatal Reproductive ToxicityTeratogenic Effects Of Drugs
Congenital malformations were induced in the offspring of pregnant Sprague-Dawley rats by the admninistration of relatively large doses of meclizine hydrochloride (Bonine). The critical period of gestation for administration was from the 12th to 15th day. Anomalies were produced in the tongue, palatal closure, mouth, lower jaw, vertebrae and limbs.
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Meclozine (“ Ancoloxin ”) and Foetal Abnormalities
G. I. Watson · BMJ · 1962 · 21 citations · Full text