Selectivity control in enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines: an efficient approach to synthesizing chiral β-amino-α-hydroxyesters

Abstract

Enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid produce beta-amino-alpha-hydroxyl acid derivatives in a single step with excellent control of chemo-, diastereo- and enantioselectivity.