Publication | Closed Access
Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines
79
Citations
43
References
2014
Year
Asymmetric CatalysisNovel OrganocatalystsEngineeringPharmacologyOrganic ChemistryCatalysisStereoselective SynthesisChemistryIsatin-derived KetiminesExcellent Diastereo-Synthetic ChemistryEnantioselective SynthesisIsatin-derived N-boc KetiminesGood Yields
The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral β-amino amides in good yields (84-97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).
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